Editorial Cuvillier

Publicaciones, tesis doctorales, capacitaciónes para acceder a una cátedra de universidad & prospectos.
Su editorial internacional especializado en ciencias y economia

Editorial Cuvillier

De En Es
A Psychobiological Perspective on the Association of Common Glucocorticoid Receptor Gene Polymorphisms with Hypothalamus-Pituitary-Adrenal Axis Regulation

Impresion
EUR 23,00 EUR 21,85

E-Book
EUR 0,00

Download
PDF (1,4 MB)
Open Access CC BY 4.0

A Psychobiological Perspective on the Association of Common Glucocorticoid Receptor Gene Polymorphisms with Hypothalamus-Pituitary-Adrenal Axis Regulation (Tienda española)

Robert Kumsta (Autor)

Previo

Indice, Datei (30 KB)
Lectura de prueba, Datei (69 KB)

The stress response has evolved as a highly adaptive reaction that ensures survival when an organism is confronted with physiological or psychological challenge. However, when occurring chronically, these responses can ultimately promote or sustain disease processes. One important stress responsive system is the hypothalamus-pituitary-adrenal (HPA) axis, a hierarchical hormonal system, which mediates the endocrine stress response. The glucocorticoid receptor (GR) plays a central role in the HPA axis regulation. Experimental work presented in this thesis is intended to contribute to a further understanding of the influence of genetic factors on the functioning of the HPA axis. The relative contributions of genetic variation of the GR on HPA axis regulation under psychosocial stress, on glucocorticoid sensitivity in three target tissues and on working memory performance were investigated. The characterization of HPA axis response phenotypes in individuals carrying different GR genotypes can be a first step in the identification of individuals who are vulnerable to or protected against the development of stress related disorders.

ISBN-10 (Impresion) 3867271550
ISBN-13 (Impresion) 9783867271554
ISBN-13 (E-Book) 9783736921559
Idioma Inglés
Numero de paginas 156
Edicion 1
Volumen 0
Lugar de publicacion Göttingen
Lugar de la disertacion Trier
Fecha de publicacion 17.02.2007
Clasificacion simple Tesis doctoral
Area Psicología
Biología
Palabras claves Stress, Hypothalamus-Hypophysen-Nebennierenrinden Achse, Glucocorticoid Rezeptor, genetische Variabilität.