Las cookies nos ayudan a ofrecer nuestros servicios. Al utilizar nuestros servicios, aceptas el uso de cookies.
De En Es
Kundenservice: +49 (0) 551 - 547 24 0

Editorial Cuvillier

Publicaciones, tesis doctorales, capacitaciónes para acceder a una cátedra de universidad & prospectos.
Su editorial internacional especializado en ciencias y economia

Editorial Cuvillier

Premiumpartner
De En Es
Titelbild-leitlinien
Sticky triangles: New tools for experimental phasing of biological macromolecules

Impresion
EUR 32,25 EUR 30,64

Sticky triangles: New tools for experimental phasing of biological macromolecules

Tobias Beck (Autor)

Previo

Indice, Datei (32 KB)
Lectura de prueba, Datei (170 KB)

ISBN-10 (Impresion) 386955729X
ISBN-13 (Impresion) 9783869557298
Idioma Inglés
Numero de paginas 194
Laminacion de la cubierta Brillante
Edicion 1 Aufl.
Volumen 0
Lugar de publicacion Göttingen
Lugar de la disertacion Universität Göttingen
Fecha de publicacion 27.04.2011
Clasificacion simple Tesis doctoral
Area Química
Geociencias
Bioquímica, biología molecular, tecnología genética
Descripcion

X-ray crystallography is the prime method for the elucidation of
three-dimensional molecular structures. The determination of novel
structures is hampered by the crystallographic phase problem. For
biological macromolecules experimental phasing is one technique to
solve this phase problem; it usually requires the incorporation of
heavy atoms in the protein crystal.
In this thesis a new class of compounds was developed that combines
heavy atoms for experimental phasing with functional groups for interaction
with biological macromolecules. Three functional groups
interact with protein residues and make the compounds sticky. Three
halogen atoms provide a strong anomalous signal and may be used
for experimental phasing. The halogen atoms form an equilateral
triangle, which is easily recognised in the heavy-atom substructure. So far
several novel protein structures have been solved with the iodine
triangle compound. The sticky compounds of the current work are
readily available and easy to use.