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Melt Extruded Drug Formulations for Individual Dosing by the Solid Dosage Pen

EUR 33,00

EUR 26,00

Melt Extruded Drug Formulations for Individual Dosing by the Solid Dosage Pen (Tienda española)

Eva Julia Laukamp (Autor)


Indice, PDF (850 KB)
Lectura de prueba, PDF (4,3 MB)

ISBN-13 (Impresion) 9783954049394
ISBN-13 (E-Book) 9783736949393
Idioma Inglés
Numero de paginas 148
Laminacion de la cubierta mate
Edicion 1. Aufl.
Lugar de publicacion Göttingen
Lugar de la disertacion Düsseldorf
Fecha de publicacion 17.03.2015
Clasificacion simple Tesis doctoral
Area Farmacia
Palabras claves Melt Extrusion, Indvidual Dosing, Controlled Drug Release, Dosing Dence, Pharmazeutische Technologie

This work focuses on the development, the manufacturing, and the characterisation of melt-extruded rods for the application by the Solid Dosage Pen – a device which permits individual dosing by cutting slices of pre-defined heights from these rods.
Tailored dissolution kinetics of the model drug carbamazepine were achieved with immediate, biphasic, and sustained release characteristics. Dose-dependent dissolution behaviour of sustained release formulations was minimised by applying a wax-coating via co-extrusion technologies and completely overcome by the embedding of coated micropellets into rods. The mechanical properties of the rods were systematically investigated by the evaluation of the maximum cutting force, the tensile strength, and the E-modulus.
To conclude, innovative production processes, new analytic methods and novel formulations were established for peroral solid dosage forms for the SDP. The melt-extruded formulations allowed for individual dosing by the SDP and could therefore provide a new platform in personalised medicine as well as in paediatrics and geriatrics.