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Photocleavable Templates for PNA Base Pairing Mediated Native Chemical Ligation

Impresion
EUR 44,40

E-Book
EUR 31,08

Photocleavable Templates for PNA Base Pairing Mediated Native Chemical Ligation

Stephen Middel (Autor)

Previo

Lectura de prueba, Datei (1,6 MB)
Indice, Datei (690 KB)

ISBN-13 (Impresion) 9783736993549
ISBN-13 (E-Book) 9783736983540
Idioma Inglés
Numero de paginas 162
Laminacion de la cubierta mate
Edicion 1.
Lugar de publicacion Göttingen
Lugar de la disertacion Göttingen
Fecha de publicacion 16.09.2016
Clasificacion simple Tesis doctoral
Area Química
Química orgánica
Palabras claves peptide ligation, templated reactions, photocleavable linker, peptide nucleic acid, native chemical ligation
Descripcion

The modification of proteins is a fundamental task in natural sciences in order to control and to understand biochemical processes. To address more complicated targets and to widen the spectrum of possible modifications, it is necessary to develop new strategies and to expand the established techniques. Herein, a novel PNA base pairing guided ligation strategy applying photocleavable templates is presented. This strategy implies the design of PNA/peptide hybrids, which are connected via a photocleavable linker. Sequence specific assembly of two PNA/peptide hybrids can be achieved by PNA base pairing. Thereby, the reactive centers are brought in close proximity and a ligation between the two hybrids is facilitated. Finally, the guiding units can be cleaved by irradiation with UV light.