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Equine Metabolic Syndrome

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Equine Metabolic Syndrome (Volumen 39) (Tienda española)

(Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses

Tobias Warnken (Autor)


Lectura de prueba, PDF (100 KB)
Indice, PDF (41 KB)

ISBN-13 (Impresion) 9783736998063
ISBN-13 (E-Book) 9783736988064
Idioma Inglés
Numero de paginas 118
Edicion 1.
Serie Wissenschaftliche Reihe der Klinik für Pferde
Volumen 39
Lugar de publicacion Göttingen
Lugar de la disertacion TiHo Hannover
Fecha de publicacion 04.06.2018
Clasificacion simple Tesis doctoral
Area Veterinaria
Palabras claves Equine Metabolic Syndrome, Insulin sensitivity, Insulin resistance, Insulin dysregulation, Lipid metabolism, Glucose homecstasis, Insulin signaling, Metabolome

Variations in insulin regulation reflect either as tissue insulin resistance or insulin dysregulation result in moderate to severe hyperinsulinemia in horses and ponies suffering from the Equine Metabolic Syndrome (EMS). Several pathomechanisms provoking equine insulin resistance have been suggested, but insulin signaling in healthy horses has not been studied in detail so far. Thus the objective of this PhD project was to investigate equine insulin sensitivity, glucose homeostasis and lipid metabolism by combining examinations of insulin signaling on a protein level in different main metabolic tissues and analyses of dynamic hormone and metabolite changes during acute stimulations by either oral glucose application or IV insulin and glucose injection. Furthermore, systemic markers of insulin resistance were analyzed by an innovative targeted metabolomics approach to provide better understanding of potential pathomechanisms involved in impaired insulin regulation in horses. In conclusion, equine-specific insulin signaling, the marginal relationship of insulin sensitivity to obesity and strong associations of high plasma insulin concentration to cellular oxidative stress depicted not only a special physiological condition but also indicate novel pathophysiological conditions underlying EMS.