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Mass Spectrometric Screening of Chiral Catalysts

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Mass Spectrometric Screening of Chiral Catalysts

Constanze Müller (Autor)

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The principle of microscopic reversibility serves as the basis of a novel screening method for the evaluation of chiral catalysts within asymmetric allylic substitution reactions. Monitoring the back reaction of quasienantiomeric products by electrospray ionisation mass spectrometry (ESI-MS) reveals the intrinsic enantioselectivity of palladium catalysts in the nucleophilic addition step and thus in the overall substitution process. As only the intrinsic selectivity is measured in the screening the effects of unselective background reaction, catalytically active
impurities and ligand dissociation do not alter the results, in contrast to product analysis.
The method was successfully applied to both linear diaryl and carbocyclic substrates.
Furthermore, a protocol for the simultaneous screening of catalyst mixtures was developed, offering new possibilities for high-throughput catalyst analysis.

ISBN-13 (Printausgabe) 3867276145
ISBN-13 (Printausgabe) 9783867276146
ISBN-13 (E-Book) 9783736926141
Sprache Englisch
Seitenanzahl 288
Auflage 1 Aufl.
Band 0
Erscheinungsort Göttingen
Promotionsort Basel
Erscheinungsdatum 09.06.2008
Allgemeine Einordnung Dissertation
Fachbereiche Chemie