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Efficient Modular Surface Modification of Biopolymers via Thermal and Photochemical Ligation Techniques

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EUR 38,40 EUR 36,48

E-Book
EUR 26,88

Efficient Modular Surface Modification of Biopolymers via Thermal and Photochemical Ligation Techniques

Thomas Tischer (Autor)

Vorschau

Inhaltsverzeichnis, PDF (59 KB)
Leseprobe, PDF (280 KB)

ISBN-13 (Printausgabe) 9783954047802
ISBN-13 (E-Book) 9783736947801
Sprache Englisch
Seitenanzahl 190
Auflage 1. Aufl.
Erscheinungsort Göttingen
Promotionsort Karlsruhe
Erscheinungsdatum 12.08.2014
Allgemeine Einordnung Dissertation
Fachbereiche Chemie
Schlagwörter Cellulose, Hyaluronan, Photo-Conjugation, Click Chemistry, hetero Diels-Alder
Beschreibung

The demand for functional biosubstrates increased substantially in the last decades through the advances in biomedicine and biosensor development. In the current thesis the modification of biosurfaces, such as cellulose and hyaluronan, via several thermally and photochemically induced ligation techniques is pioneered. The thesis is methodologically driven and aims at establishing toolbox technologies for biosurface modification. Highly efficient and mild conjugation methodologies are employed such as (hetero) Diels-Alder protocols, photoenol and phenacyl sulfide chemistry as well as the nitrile imine mediated tetrazole-ene cycloaddition (NITEC) approach to ligate polymers, peptide strands and proteins. The demonstrated arsenal of ligation protocols features mild and catalyst-free conditions, which is a vital point when handling sensitive biomolecules. Cellulose – as the most abundant and most prominent biopolymer – was placed into the focus of the current work as a platform for the establishment of a new set of ligation techniques applicable for a wide range of biosubstrates.