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2019-02-11_banner_durchlaufend_versandkostenfrei_jan-apr Titelbild-leitlinien
Bioinspired Mono- and Dinuclear Nickel, Zinc and Copper Complexes  for the Binding and Transformation of Biorelevant Substrates

Printausgabe
EUR 63,80

Bioinspired Mono- and Dinuclear Nickel, Zinc and Copper Complexes for the Binding and Transformation of Biorelevant Substrates

Natascha Bruckner (Autor)

Vorschau

Inhaltsverzeichnis, PDF (86 KB)
Leseprobe, PDF (610 KB)

ISBN-13 (Printausgabe) 9783736992511
Sprache Englisch
Seitenanzahl 252
Umschlagkaschierung matt
Auflage 1. Aufl.
Erscheinungsort Göttingen
Promotionsort Göttingen
Erscheinungsdatum 11.05.2016
Allgemeine Einordnung Dissertation
Fachbereiche Chemie
Schlagwörter hydrogen bondings, mono- and dinuclear metal complexes, phosphotriestrease, urease, dioxygen activation
Beschreibung

The synthesis of model systems is of great interest for understanding metalloenzyme active site features, and for developing biomimetic catalysts. Compartmental ligands based on macrocyclic systems and on 3,5-disubstituted pyrazolate bridges are well suited. Especially the latter ones were generated to synthesis highly preorganised bimetallic complexes with tuneable metal∙∙∙metal separations in the range 3.5‒4.5 Å. Appending second sphere functions for H-bonding interactions may enhance, in a biomimetic approach, the activation of bound substrates or the stabilisation of catalytic intermediates. With these ligands, synthetic and functional model complexes based on the proteins urease, phosphotriesterase and hemocyanin should be synthesised and characterised on their binding properties and their abilities to transform biorelevant substrates like urea, phosphoesters and dioxygen. For their characterisation and catalytical properties several analytical methods like UV/vis, IR, NMR and resonance Raman spectroscopy as well as mass spectrometry were used.