Cookies helfen uns bei der Bereitstellung unserer Dienste. Durch die Nutzung unserer Dienste erklären Sie sich damit einverstanden, dass wir Cookies setzen.
De En Es
Kundenservice: +49 (0) 551 - 547 24 0

Cuvillier Verlag

30 Jahre Kompetenz im wissenschaftlichen Publizieren
Internationaler Fachverlag für Wissenschaft und Wirtschaft

Cuvillier Verlag

Premiumpartner
De En Es
Titelbild-leitlinien
High-throughput screening and evaluation of combinatorial cell penetrating peptoid libraries to identify organelle- and organ-specific drug delivery molecules

Printausgabe
EUR 49,90

E-Book
EUR 34,90

High-throughput screening and evaluation of combinatorial cell penetrating peptoid libraries to identify organelle- and organ-specific drug delivery molecules

Ilona Diana Majella Wehl (Autor)

Vorschau

Leseprobe, PDF (790 KB)
Inhaltsverzeichnis, PDF (540 KB)

ISBN-13 (Printausgabe) 9783736999961
ISBN-13 (E-Book) 9783736989962
Sprache Englisch
Seitenanzahl 182
Umschlagkaschierung glänzend
Auflage 1.
Erscheinungsort Göttingen
Promotionsort Karlsruhe
Erscheinungsdatum 09.04.2019
Allgemeine Einordnung Dissertation
Fachbereiche Chemie
Organische Chemie
Biochemie, Molekularbiologie, Gentechnologie
Schlagwörter combinatorial synthesis, chemical biology, peptoids, drug delivery, imaging, high-throughput screening, zebrafish, organ-specific, drug delivery, fluorescence, Lipinski, structure-function relationship, fluorescent dye, cytotoxicity, spheroids
Beschreibung

Drug delivery systems can increase the pharmacokinetic and pharmacodynamic properties of various therapeutic agents. These systems can ensure a controlled release, improve the specificity of drugs to the target tissue, and therefore decrease side effects to the healthy surrounding tissue. In this work cell penetrating peptoids, which mimic the structure of peptides but exhibit increased stability, were investigated as organelle- and organ-specific carrier molecules. Several fluorescently labelled peptoid libraries, differing for example in length and side-chain composition, were synthesized and investigated with high-throughput screenings in different cell lines. The focus was on the elucidation of structure-function relationships for cellular uptake, intracellular localization and cytotoxicity. Furthermore, the organ targeting of the peptoids was analysed in in vivo studies by using zebrafish as model organism. In addition, the influence of the fluorescent dye on the localization and uptake of the peptoids was investigated.