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In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark

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EUR 24,90

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In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark (Band 51)

Lisa Annabel Weber (Autor)

Vorschau

Leseprobe, PDF (260 KB)
Inhaltsverzeichnis, PDF (160 KB)

ISBN-13 (Printausgabe) 9783736974326
ISBN-13 (E-Book) 9783736964327
Sprache Englisch
Seitenanzahl 140
Umschlagkaschierung matt
Auflage 1.
Buchreihe Wissenschaftliche Reihe der Klinik für Pferde
Band 51
Erscheinungsort Göttingen
Promotionsort Hannover
Erscheinungsdatum 25.05.2021
Allgemeine Einordnung Dissertation
Fachbereiche Veterinärmedizin
Schlagwörter Betulinsäure, NVX-207, Betulinyl-bis-sulfamat, Betulinsäure-Derivate, Triterpene, Pentazyklische Triterpenoide, Triterpene vom Lupantyp, Natürliche Wirkstoffe, Synthetisch modifizierte Wirkstoffe, Pferd, Equiden, Onkologie, Hauttumor, Neoplasie, Kutane Neoplasie, Melanom, Equines malignes Melanom, Schimmel, Equines Sarkoid, Platane, Birke, Rinde, Zellkultur, Zellkulturtest, Primärzellen, Fibroblasten, Krebszellen, Franz-Diffusionszelle, Permeationsversuche, Konzentrationsprofile, in vitro Versuch, in vivo Studie, Verträglichkeitsstudie, Wirksamkeitsstudie, Topische Behandlung, Topisches Medikament, Salbe, Creme, Behandlung, Therapie, betulinic acid, NVX-207, betulinyl-bis-sulfamate, betulinic acid derivatives, triterpenes, pentacyclic triterpenoids, lupane-type triterpenes, naturally occurring substances, synthetically modified substances, horse, equids, oncology, skin tumor, neoplasia, cutaneous neoplasia, melanoma, equine malignant melanoma, grey horse, equine sarcoid, plane tree, white birch tree, bark, cell culture, cell culture assay, primary cells, fibroblasts, cancer cells, Franz-type diffusion cell, permeation study, concentration profile, in vitro experiment, in vivo study, safety study, efficacy study, topical treatment, topical drug, ointment, cream, treatment, therapy
URL zu externer Homepage https://www.tiho-hannover.de/kliniken-institute/kliniken/klinik-fuer-pferde/team/innere-medizin/lisa-weber-phd
Beschreibung

Equine sarcoids (ES) and equine malignant melanoma (EMM) are among the tumors affecting horses diagnosed most frequently. Both cutaneous neoplasms can be a significant cause of economic losses, morbidity and mortality in the animals. The treatment of equine skin cancer can be challenging and established, evidence-based therapies resulting in sustained tumor regression are rare. The pentacyclic, lupane-type triterpenes betulinic acid (BA) and betulin can be isolated from many botanical sources, predominantly from the bark of white birch and plane trees. In addition to various biological properties, they have gained attention mainly due to their anticancer features. Within the framework of the current PhD project, the compounds BA, BA derivative NVX-207, and betulin derivative betulinyl-bis-sulfamate were assessed in various in vitro and in vivo studies for their potential as a topical therapy for ES and EMM. In conclusion, the results generated from cell culture experiments, skin permeation assays and studies in the target species are promising. Further advancement of the investigational medicinal products studied herein could lead to an effective topical and marketable, novel drug which helps to relieve suffering and, consequently, improve the welfare of equine skin cancer patients.