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DNA Bending Molecules for Improvement of Cisplatin Binding

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DNA Bending Molecules for Improvement of Cisplatin Binding (Tienda española)

Mariana Simona Damian (Autor)

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Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes with positively charged peptides was chosen as the strategy to facilitate DNA binding induced by DNA preassociation and bending of the DNA target.

ISBN-10 (Impresion) 3869555807
ISBN-13 (Impresion) 9783869555805
ISBN-13 (E-Book) 9783736935808
Idioma Inglés
Numero de paginas 170
Edicion 1 Aufl.
Volumen 0
Lugar de publicacion Göttingen
Lugar de la disertacion Universität Göttingen
Fecha de publicacion 02.12.2010
Clasificacion simple Tesis doctoral
Area Química
Bioquímica, biología molecular, tecnología genética
Palabras claves Molekularbiologie, Gentechnologie