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DNA Bending Molecules for Improvement of Cisplatin Binding

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DNA Bending Molecules for Improvement of Cisplatin Binding (Tienda española)

Mariana Simona Damian (Autor)

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ISBN-10 (Impresion) 3869555807
ISBN-13 (Impresion) 9783869555805
ISBN-13 (E-Book) 9783736935808
Idioma Inglés
Numero de paginas 170
Edicion 1 Aufl.
Volumen 0
Lugar de publicacion Göttingen
Lugar de la disertacion Universität Göttingen
Fecha de publicacion 02.12.2010
Clasificacion simple Tesis doctoral
Area Química
Bioquímica, biología molecular, tecnología genética
Palabras claves Molekularbiologie, Gentechnologie
Descripcion

Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes with positively charged peptides was chosen as the strategy to facilitate DNA binding induced by DNA preassociation and bending of the DNA target.