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DNA Bending Molecules for Improvement of Cisplatin Binding

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DNA Bending Molecules for Improvement of Cisplatin Binding (English shop)

Mariana Simona Damian (Author)


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ISBN-13 (Printausgabe) 3869555807
ISBN-13 (Hard Copy) 9783869555805
ISBN-13 (eBook) 9783736935808
Language English
Page Number 170
Edition 1 Aufl.
Volume 0
Publication Place Göttingen
Place of Dissertation Universität Göttingen
Publication Date 2010-12-02
General Categorization Dissertation
Departments Chemistry
Biochemistry, molecular biology, gene technology

Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes with positively charged peptides was chosen as the strategy to facilitate DNA binding induced by DNA preassociation and bending of the DNA target.