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DNA Bending Molecules for Improvement of Cisplatin Binding

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DNA Bending Molecules for Improvement of Cisplatin Binding (English shop)

Mariana Simona Damian (Author)

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Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes with positively charged peptides was chosen as the strategy to facilitate DNA binding induced by DNA preassociation and bending of the DNA target.

ISBN-13 (Printausgabe) 3869555807
ISBN-13 (Hard Copy) 9783869555805
ISBN-13 (eBook) 9783736935808
Language English
Page Number 170
Edition 1 Aufl.
Volume 0
Publication Place Göttingen
Place of Dissertation Universität Göttingen
Publication Date 2010-12-02
General Categorization Dissertation
Departments Chemistry
Biochemistry, molecular biology, gene technology