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DNA Bending Molecules for Improvement of Cisplatin Binding (English shop)
Mariana Simona Damian (Author)Preview
Table of Contents, Datei (50 KB)
Extract, Datei (260 KB)
| ISBN-13 (Printausgabe) | 3869555807 |
| ISBN-13 (Hard Copy) | 9783869555805 |
| ISBN-13 (eBook) | 9783736935808 |
| Language | English |
| Page Number | 170 |
| Edition | 1 Aufl. |
| Volume | 0 |
| Publication Place | Göttingen |
| Place of Dissertation | Universität Göttingen |
| Publication Date | 2010-12-02 |
| General Categorization | Dissertation |
| Departments |
Chemistry
Biochemistry, molecular biology, gene technology |
Description
Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes with positively charged peptides was chosen as the strategy to facilitate DNA binding induced by DNA preassociation and bending of the DNA target.
