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Leitlinien Unfallchirurgie
5. Auflage bestellen |
Table of Contents, Datei (50 KB)
Extract, Datei (260 KB)
ISBN-13 (Printausgabe) | 3869555807 |
ISBN-13 (Hard Copy) | 9783869555805 |
ISBN-13 (eBook) | 9783736935808 |
Language | English |
Page Number | 170 |
Edition | 1 Aufl. |
Volume | 0 |
Publication Place | Göttingen |
Place of Dissertation | Universität Göttingen |
Publication Date | 2010-12-02 |
General Categorization | Dissertation |
Departments |
Chemistry
Biochemistry, molecular biology, gene technology |
Modification of the anticancer drug cisplatin was investigated by designing hybrid molecules of the platinum moiety with peptide motifs. New cisplatin analogs were synthesized and DNA interaction studies were performed. A mixture of cationic metal complexes with positively charged peptides was chosen as the strategy to facilitate DNA binding induced by DNA preassociation and bending of the DNA target.