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Leitlinien Unfallchirurgie
5. Auflage bestellen |
Lectura de prueba, PDF (1,3 MB)
Indice, PDF (620 KB)
ISBN-13 (Impresion) | 9783736999138 |
ISBN-13 (E-Book) | 9783736989139 |
Idioma | Inglés |
Numero de paginas | 144 |
Laminacion de la cubierta | mate |
Edicion | 1. |
Serie | Hochschulschriften - Institut für Systembiotechnologie, Universität des Saarlandes |
Volumen | 7 |
Lugar de publicacion | Göttingen |
Lugar de la disertacion | Saarbrücken |
Fecha de publicacion | 06.12.2018 |
Clasificacion simple | Tesis doctoral |
Area |
Microbiología y biotécnica
|
Palabras claves | bio-succinic acid,bacterium Basfia , carbon-three chemicals |
The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, β-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for β-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.