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Editorial Cuvillier

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Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds

Impresion
EUR 41,80

E-Book
EUR 29,30

Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds (Volumen 7) (Tienda española)

Jonathan Thomas Fabarius (Autor)

Previo

Lectura de prueba, PDF (1,3 MB)
Indice, PDF (620 KB)

ISBN-13 (Impresion) 9783736999138
ISBN-13 (E-Book) 9783736989139
Idioma Inglés
Numero de paginas 144
Laminacion de la cubierta mate
Edicion 1.
Serie Hochschulschriften - Institut für Systembiotechnologie, Universität des Saarlandes
Volumen 7
Lugar de publicacion Göttingen
Lugar de la disertacion Saarbrücken
Fecha de publicacion 06.12.2018
Clasificacion simple Tesis doctoral
Area Microbiología y biotécnica
Palabras claves bio-succinic acid,bacterium Basfia , carbon-three chemicals
Descripcion

The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, β-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for β-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.