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Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds

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Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds (Volume 7) (English shop)

Jonathan Thomas Fabarius (Author)

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ISBN-13 (Hard Copy) 9783736999138
ISBN-13 (eBook) 9783736989139
Language English
Page Number 144
Lamination of Cover matt
Edition 1.
Book Series Hochschulschriften - Institut für Systembiotechnologie, Universität des Saarlandes
Volume 7
Publication Place Göttingen
Place of Dissertation Saarbrücken
Publication Date 2018-12-06
General Categorization Dissertation
Departments Microbiology and biotechnology
Keywords bio-succinic acid,bacterium Basfia , carbon-three chemicals
Description

The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, β-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for β-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.