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Editorial Cuvillier

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Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties

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Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties (Tienda española)

Hermann Broder Schmidt (Autor)

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Lectura de prueba, PDF (460 KB)
Indice, PDF (110 KB)

ISBN-13 (Impresion) 9783954044917
Idioma Inglés
Numero de paginas 172
Laminacion de la cubierta mate
Edicion 1. Aufl.
Lugar de publicacion Göttingen
Lugar de la disertacion Göttingen
Fecha de publicacion 23.08.2013
Clasificacion simple Tesis doctoral
Area Bioquímica, biología molecular, tecnología genética
Palabras claves Nuclear pore, nuclear transport, FG repeats, permeability barrier, hydrogels
Descripcion

Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain ‘cohesive’ FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.