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Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties

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Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties

Hermann Broder Schmidt (Autor)

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Inhaltsverzeichnis, PDF (110 KB)

ISBN-13 (Printausgabe) 9783954044917
Sprache Englisch
Seitenanzahl 172
Umschlagkaschierung matt
Auflage 1. Aufl.
Erscheinungsort Göttingen
Promotionsort Göttingen
Erscheinungsdatum 23.08.2013
Allgemeine Einordnung Dissertation
Fachbereiche Biochemie, Molekularbiologie, Gentechnologie
Schlagwörter Nuclear pore, nuclear transport, FG repeats, permeability barrier, hydrogels
Beschreibung

Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain ‘cohesive’ FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.