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Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties

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Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties (English shop)

Hermann Broder Schmidt (Author)

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ISBN-13 (Hard Copy) 9783954044917
Language English
Page Number 172
Lamination of Cover matt
Edition 1. Aufl.
Publication Place Göttingen
Place of Dissertation Göttingen
Publication Date 2013-08-23
General Categorization Dissertation
Departments Biochemistry, molecular biology, gene technology
Keywords Nuclear pore, nuclear transport, FG repeats, permeability barrier, hydrogels
Description

Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain ‘cohesive’ FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.