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Comparison of various methods for quantification of equine insulin under clinical settings for assessment of insulin dysregulation

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Comparison of various methods for quantification of equine insulin under clinical settings for assessment of insulin dysregulation (Volumen 45) (Tienda española)

Tobias Warnken (Autor)

Previo

Lectura de prueba, PDF (610 KB)
Indice, PDF (580 KB)

ISBN-13 (Impresion) 9783736971240
ISBN-13 (E-Book) 9783736961241
Idioma Inglés
Numero de paginas 140
Laminacion de la cubierta mate
Edicion 1.
Serie Wissenschaftliche Reihe der Klinik für Pferde
Volumen 45
Lugar de publicacion Göttingen
Lugar de la disertacion TiHo Hannover
Fecha de publicacion 02.12.2019
Clasificacion simple Tesis doctoral
Area Veterinaria
Palabras claves metabolic syndrome, insulin dysregulation, equine population
Descripcion

The equine metabolic syndrome is a significant problem and health concern in the equine population. Impaired insulin regulation reflected by basal or pathological postprandial hyperinsulinemia and caused by insulin dysregulation (ID) and/or insulin resistance (IR) is the major key finding and clearly linked to the severe and life-threating sequel laminitis. However, besides various diagnostic approaches for assessment of disturbed insulin regulation under basal conditions or under dynamic stimulation, striking differences in performance of immunoassays used for quantification of equine insulin occurred. Therefore, the objective of this research project was firstly to evaluate various methods used for quantification of equine insulin under consideration of clinical demands and conditions and secondly to optimize assessment of equine ID and IR by a combination of appropriate dynamic diagnostic testing and quantification of equine insulin with an reliable and appropriate immunoassay method.