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Comparison of various methods for quantification of equine insulin under clinical settings for assessment of insulin dysregulation

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Comparison of various methods for quantification of equine insulin under clinical settings for assessment of insulin dysregulation (Volume 45) (English shop)

Tobias Warnken (Author)

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ISBN-13 (Hard Copy) 9783736971240
ISBN-13 (eBook) 9783736961241
Language English
Page Number 140
Lamination of Cover matt
Edition 1.
Book Series Wissenschaftliche Reihe der Klinik für Pferde
Volume 45
Publication Place Göttingen
Place of Dissertation TiHo Hannover
Publication Date 2019-12-02
General Categorization Dissertation
Departments Veterinary medicine
Keywords metabolic syndrome, insulin dysregulation, equine population
Description

The equine metabolic syndrome is a significant problem and health concern in the equine population. Impaired insulin regulation reflected by basal or pathological postprandial hyperinsulinemia and caused by insulin dysregulation (ID) and/or insulin resistance (IR) is the major key finding and clearly linked to the severe and life-threating sequel laminitis. However, besides various diagnostic approaches for assessment of disturbed insulin regulation under basal conditions or under dynamic stimulation, striking differences in performance of immunoassays used for quantification of equine insulin occurred. Therefore, the objective of this research project was firstly to evaluate various methods used for quantification of equine insulin under consideration of clinical demands and conditions and secondly to optimize assessment of equine ID and IR by a combination of appropriate dynamic diagnostic testing and quantification of equine insulin with an reliable and appropriate immunoassay method.