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Editorial Cuvillier

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Pharmacological preconditioning and ischaemic postconditioning in experimental jejunal ischaemia in horses

EUR 24,90

EUR 18,90

Pharmacological preconditioning and ischaemic postconditioning in experimental jejunal ischaemia in horses (Volumen 52) (Tienda española)

Nicole Verhaar (Autor)


Lectura de prueba, PDF (460 KB)
Indice, PDF (46 KB)

ISBN-13 (Impresion) 9783736974333
ISBN-13 (E-Book) 9783736964334
Idioma Inglés
Numero de paginas 146
Edicion 1.
Serie Wissenschaftliche Reihe der Klinik für Pferde
Volumen 52
Lugar de publicacion Göttingen
Lugar de la disertacion Hannover
Fecha de publicacion 01.06.2021
Clasificacion simple Tesis doctoral
Area Veterinaria
Palabras claves Ischämie, Ischaemia, Ischemia, Ischämisch, Ischaemic, Ischemic, Conditioning, Konditionierung, Preconditioning, Präkonditonierung, Postconditioning, Postkonditionierung, Remote conditioning, Small intestine, Dünndarm, Bowel, Jejunum, Ileum, Reperfusion, Inflammation , Oxidative stress, Oxygen radical, Resection, Clamping, Reocclusion, Intestinal blood flow, Kolik, Colic, Laparotomy, laparotomie, Koliker, Abdominal pain, Xylazine, Xylazine, Lidocaine, Lidocaine, Lignocaine, Sedation, Anaesthesia, Anesthesia, Anästhesie, Analgesia, Analgäsie, Low-flow, Histomorphology, Histomorphometry, Chiu score, Apoptosis, Cell death, Caspase, Calprotectin, TUNEL, Malondialdehyde, Myeloperoxidase, Superoxide dismutase, Hypoxia inducible factor, HIF-1alpha, HIF-2alpha, Heat shock response, Heat shock protein-70, HSP-70

Strangulating obstruction of the small intestine in the horse is associated with a high mortality rate. Although many intestinal lesions can be treated surgically, more effective strategies are needed to decrease the occurrence of complications related to the intestinal segments that are not amenable to intestinal resection. The aim of this PhD was to determine the feasibility and effect of two novel treatment modalities in equine small intestinal ischaemia. Therefore, ischaemic postconditioning and pharmacological preconditioning with lidocaine and xylazine were investigated in two experimental in vivo studies. By evaluating different variables for intestinal ischaemia reperfusion injury by use of histomorphology, immunohistochemistry and biochemical analysis, the results of this study demonstrate the applicability of these treatments in experimental small intestinal ischaemia in horses.