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Cuvillier Verlag

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Pharmacological preconditioning and ischaemic postconditioning in experimental jejunal ischaemia in horses

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EUR 24,90

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EUR 18,90

Pharmacological preconditioning and ischaemic postconditioning in experimental jejunal ischaemia in horses (Band 52)

Nicole Verhaar (Autor)

Vorschau

Leseprobe, PDF (460 KB)
Inhaltsverzeichnis, PDF (46 KB)

ISBN-13 (Printausgabe) 9783736974333
ISBN-13 (E-Book) 9783736964334
Sprache Englisch
Seitenanzahl 146
Auflage 1.
Buchreihe Wissenschaftliche Reihe der Klinik für Pferde
Band 52
Erscheinungsort Göttingen
Promotionsort Hannover
Erscheinungsdatum 01.06.2021
Allgemeine Einordnung Dissertation
Fachbereiche Veterinärmedizin
Schlagwörter Ischämie, Ischaemia, Ischemia, Ischämisch, Ischaemic, Ischemic, Conditioning, Konditionierung, Preconditioning, Präkonditonierung, Postconditioning, Postkonditionierung, Remote conditioning, Small intestine, Dünndarm, Bowel, Jejunum, Ileum, Reperfusion, Inflammation , Oxidative stress, Oxygen radical, Resection, Clamping, Reocclusion, Intestinal blood flow, Kolik, Colic, Laparotomy, laparotomie, Koliker, Abdominal pain, Xylazine, Xylazine, Lidocaine, Lidocaine, Lignocaine, Sedation, Anaesthesia, Anesthesia, Anästhesie, Analgesia, Analgäsie, Low-flow, Histomorphology, Histomorphometry, Chiu score, Apoptosis, Cell death, Caspase, Calprotectin, TUNEL, Malondialdehyde, Myeloperoxidase, Superoxide dismutase, Hypoxia inducible factor, HIF-1alpha, HIF-2alpha, Heat shock response, Heat shock protein-70, HSP-70
Beschreibung

Strangulating obstruction of the small intestine in the horse is associated with a high mortality rate. Although many intestinal lesions can be treated surgically, more effective strategies are needed to decrease the occurrence of complications related to the intestinal segments that are not amenable to intestinal resection. The aim of this PhD was to determine the feasibility and effect of two novel treatment modalities in equine small intestinal ischaemia. Therefore, ischaemic postconditioning and pharmacological preconditioning with lidocaine and xylazine were investigated in two experimental in vivo studies. By evaluating different variables for intestinal ischaemia reperfusion injury by use of histomorphology, immunohistochemistry and biochemical analysis, the results of this study demonstrate the applicability of these treatments in experimental small intestinal ischaemia in horses.