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Biological and Chemical Investigations of Indonesian Marine-Derived Fungi and their Secondary Metabolites

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Biological and Chemical Investigations of Indonesian Marine-Derived Fungi and their Secondary Metabolites

Kustiariyah Tarman (Autor)

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In the search for bioactive compounds, 32 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. Bioassay-guided fractionation led to the isolation of bioactive compounds. Altogether 14 compounds were isolated and further elucidated. The compounds were obtained from the ethyl acetate and dichloromethane extracts of six fungal strains. They included 9 polyketides, 2 terpenes, 1 alkaloid and 2 till now undefined structures.

ISBN-13 (Printausgabe) 3869557133
ISBN-13 (Printausgabe) 9783869557137
ISBN-13 (E-Book) 9783736937130
Sprache Englisch
Seitenanzahl 198
Auflage 1 Auflage
Band 0
Erscheinungsort Göttingen
Promotionsort Universität Greifswald
Erscheinungsdatum 04.04.2011
Allgemeine Einordnung Dissertation
Fachbereiche Biochemie, Molekularbiologie, Gentechnologie