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Biological and Chemical Investigations of Indonesian Marine-Derived Fungi and their Secondary Metabolites

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Biological and Chemical Investigations of Indonesian Marine-Derived Fungi and their Secondary Metabolites (English shop)

Kustiariyah Tarman (Author)

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ISBN-13 (Printausgabe) 3869557133
ISBN-13 (Hard Copy) 9783869557137
ISBN-13 (eBook) 9783736937130
Language English
Page Number 198
Edition 1 Auflage
Volume 0
Publication Place Göttingen
Place of Dissertation Universität Greifswald
Publication Date 2011-04-04
General Categorization Dissertation
Departments Biochemistry, molecular biology, gene technology
Keywords Indonesian marine fungi, algicolous fungi, anticancer, bioactive compounds
Description

In the search for bioactive compounds, 32 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. Bioassay-guided fractionation led to the isolation of bioactive compounds. Altogether 14 compounds were isolated and further elucidated. The compounds were obtained from the ethyl acetate and dichloromethane extracts of six fungal strains. They included 9 polyketides, 2 terpenes, 1 alkaloid and 2 till now undefined structures.