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Editorial Cuvillier

Publicaciones, tesis doctorales, capacitaciónes para acceder a una cátedra de universidad & prospectos.
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Editorial Cuvillier

New Algorithms for Single Particle Cryo Electron Microscopic Image Processing

Impresion
EUR 36,80

New Algorithms for Single Particle Cryo Electron Microscopic Image Processing (Tienda española)

Jan-Martin Kirves (Autor)

Previo

Indice, PDF (31 KB)
Lectura de prueba, PDF (220 KB)

ISBN-13 (Impresion) 9783954049073
Idioma Inglés
Numero de paginas 174
Laminacion de la cubierta mate
Edicion 1. Aufl.
Lugar de publicacion Göttingen
Lugar de la disertacion Göttingen
Fecha de publicacion 06.01.2015
Clasificacion simple Tesis doctoral
Area Informática
Biología
Microbiología y biotécnica
Palabras claves cyro electron microscopy, validation, quality criteris, sample optimization, software
Descripcion

In this thesis four approaches to increase the quality and assure the validity of three-dimensional (3D) models generated within the single particle cryo-electron microscopy (CryoEM) workflow are introduced. ProteoPlex is a high-throughput technique and software tool for the evaluation of the most stabilizing biochemical conditions of macromolecular complexes. The validation technique 3D correlation of tilted pairs (3DCTP) can be applied alongside the single particle refinement cycle to detect model bias utilizing tilted pair images. A new analysis method identifies the presence of overfitting in high resolution CryoEM 3D structures. Finally, a set of criteria covering different model quality aspects of the generated 3D structure is introduced.