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New Algorithms for Single Particle Cryo Electron Microscopic Image Processing (Tienda española)
Jan-Martin Kirves (Autor)Previo
Indice, PDF (31 KB)
Lectura de prueba, PDF (220 KB)
| ISBN-13 (Impresion) | 9783954049073 |
| Idioma | Inglés |
| Numero de paginas | 174 |
| Laminacion de la cubierta | mate |
| Edicion | 1. Aufl. |
| Lugar de publicacion | Göttingen |
| Lugar de la disertacion | Göttingen |
| Fecha de publicacion | 06.01.2015 |
| Clasificacion simple | Tesis doctoral |
| Area |
Informática
Biología Microbiología y biotécnica |
| Palabras claves | cyro electron microscopy, validation, quality criteris, sample optimization, software |
Descripcion
In this thesis four approaches to increase the quality and assure the validity of three-dimensional (3D) models generated within the single particle cryo-electron microscopy (CryoEM) workflow are introduced. ProteoPlex is a high-throughput technique and software tool for the evaluation of the most stabilizing biochemical conditions of macromolecular complexes. The validation technique 3D correlation of tilted pairs (3DCTP) can be applied alongside the single particle refinement cycle to detect model bias utilizing tilted pair images. A new analysis method identifies the presence of overfitting in high resolution CryoEM 3D structures. Finally, a set of criteria covering different model quality aspects of the generated 3D structure is introduced.
