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Leitlinien Unfallchirurgie
5. Auflage bestellen |
Extract, PDF (66 KB)
Table of Contents, PDF (68 KB)
ISBN-13 (Hard Copy) | 9783954045723 |
ISBN-13 (eBook) | 9783736945722 |
Language | English |
Page Number | 72 |
Edition | 1 Aufl. |
Publication Place | Göttingen |
Place of Dissertation | Zürich |
Publication Date | 2014-01-29 |
General Categorization | Dissertation |
Departments |
Psychology
Human medicine |
Keywords | bulimia nervosa, catecholamine depletion, dopamine, norepinephrine, pathophysiology, behavioral effects, reward, Psychiatrie und psychologische Medizin |
This thesis consists of two reports focusing on the role of catecholaminergic function in the pathophysiologic mechanism of bulimia nervosa (BN). The study presented in Report 1 and in Report 2 is the first, to our knowledge, that applied the paradigm of catecholamine depletion in unmedicated remitted female subjects with bulimia nervosa (rBN) and healthy controls. In Report 1 the aim of the study was to examine a hypothesized catecholaminergic dysfunction in the pathogenesis of BN by assessing behavioral effects of catecholamine depletion in rBN. Report 2 investigated whether responses of the brain reward system using a probabilistic reward task differ between remitted female subjects with BN and healthy female controls following catecholamine depletion. Our findings support the notion of catecholaminergic dysfunction as a possible trait abnormality in BN. Moreover our results support the belief of a disturbance of the central reward processing system in rBN related to altered brain catecholamine levels.