Optimierung trägerbasierter Pulverinhalate durch Modifikation der Trägeroberfläche mittels Sprühtrocknung (English shop)

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Stephan Gerhard Maas’s dissertation investigates the optimization of carrier-based dry powder inhalers through controlled modification of particle surfaces using spray drying. The research focuses on mannitol as an alternative carrier material to lactose, offering improved storage stability due to its crystalline structure. By varying spray-drying parameters, particularly outlet air temperature, different particle surface morphologies are produced and characterized. Scanning electron microscopy and confocal laser microscopy are employed to examine particle morphology and surface roughness. Additional investigations address crystallization behavior, polymorphic forms, powder flow properties, and mechanical stability. To evaluate pharmaceutical performance, interactive powder mixtures containing spray-dried mannitol and micronized salbutamol sulfate are prepared. Experimental results demonstrate that smooth carrier surfaces facilitate drug particle detachment during inhalation, resulting in higher respirable drug fractions. In contrast, rough surfaces and particle cavities can hinder drug release by increasing mechanical retention. The findings highlight the potential of controlled carrier surface modification to improve the aerodynamic performance and overall quality of dry powder inhalation formulations.