Infected Biomaterials New Strategies For Local Anti-Infective Treatment (English shop)

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This dissertation investigates novel strategies for preventing and locally treating infections associated with medical biomaterials, particularly vascular grafts and surgical sutures. The research focuses on antimicrobial coatings based on biodegradable drug delivery systems that provide controlled local release of antibiotics and antiseptics. Experimental investigations evaluate drug release characteristics, bacterial adhesion, antimicrobial activity, biocompatibility, and haemocompatibility. Furthermore, the study examines the effects of low-frequency electric and electromagnetic fields on Staphylococcus aureus growth and antibiotic efficacy. Additional research explores magnetic drug targeting using superparamagnetic iron oxide nanoparticles and the functional neurotoxicity of antibiotics investigated through mammalian neuronal networks cultured on microelectrode arrays. The findings demonstrate promising approaches to localized infection control while highlighting the importance of material compatibility, drug safety, and further experimental investigation.