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Leitlinien Unfallchirurgie
5. Auflage bestellen |
Table of Contents, Datei (69 KB)
Extract, Datei (240 KB)
ISBN-13 (Printausgabe) | 3869559780 |
ISBN-13 (Hard Copy) | 9783869559780 |
ISBN-13 (eBook) | 9783736939783 |
Language | English |
Page Number | 205 |
Lamination of Cover | glossy |
Edition | 1 Aufl. |
Volume | 0 |
Publication Place | Göttingen |
Place of Dissertation | Göttingen |
Publication Date | 2011-12-22 |
General Categorization | Dissertation |
Departments |
Chemistry
|
Enzymes with multicopper active sites play important roles in many biological processes. Recently a novel multinuclear copper site was discovered in N2O-Reductase and its exact structure and mechanism has been much discussed since then. The so called CuZ center contains a unique tetranuclear Cu4S2-Cluster, which is coordinated by seven histidine residues. Until now no synthetic model complex could be isolated that emulates the Cu4S2 core of the active site.
In this thesis a new strategy towards such model systems is introduced. To mimic the nitrogen-rich environment of the copper ions, pyrazolate-based ligand scaffolds with chelating N-donor side arms are employed. The resulting binuclear metal complexes were isolated and fully characterized. Additionally the reactivity of these binuclear building blocks towards various sulfur-containing coligands and sulfur-transfer reagents was investigated.