Synthese von Cephalotaxin und Analoga durch Palladium-Katalyse und neuartige Domino-Reaktionen (English shop)

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The complex ring systems of Cephalotaxus alkaloids present a significant challenge for modern organic synthetic chemistry.
In this transformation, primary amines activated with trimethylaluminum react with unsaturated esters to form complex spirocyclic structures.
Investigations involving different substrates demonstrate the applicability of this methodology to various functional groups and ring sizes.
Subsequent palladium-catalyzed enolate arylation provides access to additional polycyclic cephalotaxine analogues.
Further studies explore synthetic approaches toward cephalotaxidine, including stereoselective aldol reactions and additional palladium-catalyzed cyclizations.
Overall, the dissertation expands the methodological possibilities of natural product synthesis and demonstrates efficient strategies for constructing complex nitrogen-containing ring systems.