Einsatz magnetisierbarer Partikelsysteme in der Bioverfahrenstechnik (English shop)

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In recent years, nanoparticles have increasingly become a focus of research. The exceptional physicochemical properties of these particles open up a broad field of potential applications in various scientific areas. To date, magnetic particles have scarcely been used in large-scale industrial processes. Using three examples from the fields of hydrolysis, catalysis and the downstream processing of antibiotics, possible areas of application are presented and the potential for use in a bioprocess engineering process is discussed.

In the first example, magnetic nanoparticles are used as carriers for a biocatalyst. Their magnetic characteristics allow the particles to be easily recovered and thus reused in the process. In the second part of the work, gold nanoparticles are employed for the supported-catalyst conversion of glucose to gluconic acid. The catalytic conversion achieved by the particles is comparable to the fermentation used for the large-scale production of the acid and thus represents a competitive alternative to existing processes. As a final example, magnetic particles were used as adsorbents in the purification of lactam antibiotics; by employing a high-gradient magnetic separator optimised for bioprocesses, they markedly reduce the number of purification steps in antibiotic recovery.