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Biomarkers of acid-base status  and their interrelationships with body fatness, glucocorticoids,  and height

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Biomarkers of acid-base status and their interrelationships with body fatness, glucocorticoids, and height (English shop)

Yifan Hua (Author)


Extract, PDF (790 KB)
Table of Contents, PDF (160 KB)

ISBN-13 (Hard Copy) 9783736976184
ISBN-13 (eBook) 9783736966185
Language English
Page Number 128
Lamination of Cover glossy
Edition 1.
Publication Place Göttingen
Place of Dissertation Bonn
Publication Date 2022-05-09
General Categorization Dissertation
Departments Domestic and nutritional science
Keywords Aminosäure, Adrenocorticotrope Hormon, Erwachsenengröße, Age at peak height velocity, Age at take-off, Body mass index, Körperfettanteil, Körperoberfläche, Transcortin, Chronisches Nierenleiden, Corticotropin-Releasing-Hormon, DONALD Studie, Fettmassenindex, Früchte und Gemüse, Glucocorticoide, Wachstumshormone, Wachstumshormon freisetzendes Hormon, Hypothalamus-Hypophyse-Nebennieren, Insulinähnliche Wachstumsfaktor-1, Niedriggradige metabolische Azidose, Mineralokortikoidrezeptor, Net acid excretion, Net acid excretion capacity, Organische Säure, Potential renal acid load, Dietary potential renal acid load, Urinary potential renal acid load, Renale tubuläre Azidose, Lösliches interzelluläres Adhäsionsmolekül-1, Titrierfähige Säure, Tetrahydrocortison, Tetrahydrocortisol, Freies Cortison im Urin, Freies Cortisol im Urin, Urin-Harnstoff-Stickstoff, Taillenumfang, 6β-hydroxycortisol, 11β-hydroxysteroid dehydrogenase type 1, 11β-hydroxysteroid dehydrogenase type 2, 20α-dihydrocortisol, Amino acid, Adrenocorticotropic hormone, Adult height, Body fat percent, Body surface area, Cortisol binding globulin, Chronic kidney disease, Corticotropin releasing hormone, DONALD Study, Fat mass index, Fruits and vegetables, Glucocorticoid, Growth hormone, Growth hormone releasing hormone, Hypothalamic-pituitary-adrenal, Insulin-like growth factor-1, Low-grade metabolic acidosis, Mineralocorticoid receptor, Organic acid, Renal tubular acidosis, Soluble intercellular adhesion molecule-1, Titratable acid, Tetrahydrocortisone, Tetrahydrocortisol, Urinary free cortisone, Urinary free cortisol, Urinary urea nitrogen, Waist circumference
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Acid-base homeostasis is essential for human health and a variety of physiological conditions. Pathophysiological changes can result in acid-base derangements, which can be accompanied by acute and long-term metabolic disorders. Moreover, even a narrow change of blood pH still within the physiological change, e.g., a diet-induced shift towards a more acidic status, has been reported to already cause adverse health consequences. Against this background, we aimed to, by using non-invasive urinary biomarkers, examine acid-base-related physiological and epidemiological relationships of body fatness with 24-h urine pH, the potential mediatory roles of inflammatory biomarkers in the high body fat–low urine pH relation, and the association between 24-h urinary glucocorticoid excretion and renal citrate output, as well as the prospective relationships of protein intake and dietary acid load during childhood and adolescence with adult height. All study participants were selected and data came from the DOrtmund Nutritional and Antropometric Longitudinally Designed (DONALD) Study, which includes regular examinations on dietary intake, metabolism, and growth in healthy children and adolescents until their adulthood without particular pre-specified endpoints.