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Equine Metabolic Syndrome

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Equine Metabolic Syndrome (Volume 59) (English shop)

Glucose and lipid metabolism in metabolically and endocrinologically diseased horses

Florian Frers (Author)


Extract, PDF (190 KB)
Table of Contents, PDF (89 KB)

ISBN-13 (Hard Copy) 9783736978058
ISBN-13 (eBook) 9783736968059
Language English
Page Number 112
Lamination of Cover matt
Edition 1.
Book Series Wissenschaftliche Reihe der Klinik für Pferde
Volume 59
Publication Place Göttingen
Place of Dissertation Hannover
Publication Date 2023-06-08
General Categorization Dissertation
Departments Veterinary medicine
Common veterinary medicin
Specific veterinary medicine
Keywords Equines Metabolisches Syndrom, EMS, Pituitary Pars Intermedia Dysfunction, PPID, Insulin, Glucose, Insulinsignalkaskade, Schlüsselprotein, Oraler Glukose Test, Insulin-Stimulationstest, 2-Stufen Insulin-Stimulationstest, 2-Stufen IST, Glukosehomöostase, Hufrehe, Endokrinopathisch, Hyperinsulinämie, Pferd, Islandpferd, Adipositas, Regionale Fettdepots, Western Blot, Protein, Diagnostik, Phosphorylierung, Mechanistic target of rapamycin, mTOR, Insulin Rezeptor, InsR, Proteinkinase B, PKB/Akt, Proteinstoffwechsel, Equine metabolic syndrome, Insulin signaling cascade, Key protein, Oral glucose test, Insulin response test, 2-step insulin response test, 2-step IRT, Glucose homeostasis, Laminitis, Endocrinopathic, Hyperinsulinemia, Equine, Icelandic horse, Adiposity, Regional fat accumulation, Western Blot, Diagnostics, Phosphorylation, Mechanistic target of rapamycin, mTOR, Insulin receptor, Protein kinase B, Protein metabolism

The term insulin dysregulation encompasses different disturbances of insulin regulation in equids, including basal or a pathological high postprandial hyperinsulinemia and/or peripheral insulin resistance. Alterations of insulin signaling, as seen in human type II diabetes mellitus, might be associated with the development of insulin dysregulation, but the underlying pathomechanisms have not been elucidated yet. Therefore, the objective of this study was to determine key proteins of the insulin signaling cascade in insulin dysregulated and healthy horses under basal conditions and after an oral glucose and intravenous insulin challenge. Secondly, the insulin and glucose response to an IV insulin and oral glucose challenge was described to assess glucose and insulin dynamics following different challenges. In principle, insulin signaling was maintained, but the signaling cascade was modified, especially at post-receptor events, in relation to the source of insulin. Thus, ID seems to be an equine-specific metabolic condition, in which alterations of the mTOR signaling pathway may play a crucial role, emphasized by higher mTOR phosphorylation in ID horses. Furthermore, the results of the study support that both terms, hyperinsulinemia and insulin resistance, have to be clearly distinguished in the context of insulin dysregulation.