Synthese und biologische Evaluierung von Azaanthracenonen (English shop)

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The present work deals with the natural product class of the azaanthracenones. Several members of this class of compounds have been isolated from plants of the Annonaceae family over the past three decades and exhibit cytotoxic properties against human tumour cells. This work describes, for the first time, efficient and divergent synthetic strategies for this class of natural products. Based on these synthetic routes, numerous derivatives were prepared and tested for their activity against human cancer cell lines in cytotoxicity studies. In the course of this, several derivatives of the natural products with markedly enhanced potency were identified. Through rational design, these compounds could be further optimised and structure–activity relationships established.