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Function of microRNAs in skeletal muscle cell differentiation (English shop)
Swanhild Meyer (Author)Preview
Extract, PDF (360 KB)
Table of Contents, PDF (74 KB)
| ISBN-13 (Hard Copy) | 9783736993068 |
| ISBN-13 (eBook) | 9783736983069 |
| Language | English |
| Page Number | 92 |
| Lamination of Cover | matt |
| Edition | 1. Aufl. |
| Publication Place | Göttingen |
| Place of Dissertation | TU München |
| Publication Date | 2016-07-27 |
| General Categorization | Dissertation |
| Departments |
Biochemistry, molecular biology, gene technology
|
| Keywords | micro-RNA, skeletalmuscle, myoblast, target prediction, microarray, real-time qPCR, normalization, geneexpression, cell differentiation |
Description
Skeletal muscle cell differentiation is exogenously regulated by cytokines and growth factors and it is post-transcriptionally regulated by microRNAs (miRNAs). This study presents miRNA and gene expression data of differentiating skeletal muscles with or without concomitant TNF-alpha or IGF1 exposure to elucidate the function of miRNAs. Results indicate specific miRNA-target relations during skeletal muscle differentiation and show that miRNAs mediate the effect of TNF-alpha.
