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Function of microRNAs in skeletal muscle cell differentiation

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Function of microRNAs in skeletal muscle cell differentiation (English shop)

Swanhild Meyer (Author)

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ISBN-13 (Hard Copy) 9783736993068
ISBN-13 (eBook) 9783736983069
Language English
Page Number 92
Lamination of Cover matt
Edition 1. Aufl.
Publication Place Göttingen
Place of Dissertation TU München
Publication Date 2016-07-27
General Categorization Dissertation
Departments Biochemistry, molecular biology, gene technology
Keywords micro-RNA, skeletalmuscle, myoblast, target prediction, microarray, real-time qPCR, normalization, geneexpression, cell differentiation
Description

Skeletal muscle cell differentiation is exogenously regulated by cytokines and growth factors and it is post-transcriptionally regulated by microRNAs (miRNAs). This study presents miRNA and gene expression data of differentiating skeletal muscles with or without concomitant TNF-alpha or IGF1 exposure to elucidate the function of miRNAs. Results indicate specific miRNA-target relations during skeletal muscle differentiation and show that miRNAs mediate the effect of TNF-alpha.