eNOS Derived Oxidative Stress and its Role in the Regulation of Blood Pressure (English shop)

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Essential hypertension is associated with endothelial dysfunction, and reactive oxygen species appear to play a role in this. To what extent endothelial superoxide radical anion plays a role in the early stage of the development of hypertension is not yet known. This study investigates whether oxidative stress mediated by endothelial nitric oxide synthase (eNOS) in the endothelium is involved in the regulation of systolic blood pressure. For this purpose, two different eNOS variants are overexpressed endothelium-specifically in C57BL/6 mice. It can be shown that oxidative stress caused by endothelium-specific overexpression of genetically destabilised C101A-eNOS selectively prevents the blood pressure-lowering effect of vascular eNOS, whereas there is no effect on endothelium-dependent relaxation in the aorta. These data indicate that reduced eNOS dimer stability, which is associated with vascular oxidative stress in the microvascular endothelium, may be directly involved in the regulation of blood pressure and could thus play a role in the development of essential hypertension.